![Frontiers | Dynorphin/kappa opioid receptor system regulation on amygdaloid circuitry: Implications for neuropsychiatric disorders Frontiers | Dynorphin/kappa opioid receptor system regulation on amygdaloid circuitry: Implications for neuropsychiatric disorders](https://www.frontiersin.org/files/MyHome%20Article%20Library/963691/963691_Thumb_400.jpg)
Frontiers | Dynorphin/kappa opioid receptor system regulation on amygdaloid circuitry: Implications for neuropsychiatric disorders
![Lowered endogenous mu-opioid receptor availability in subclinical depression and anxiety | Neuropsychopharmacology Lowered endogenous mu-opioid receptor availability in subclinical depression and anxiety | Neuropsychopharmacology](https://media.springernature.com/full/springer-static/image/art%3A10.1038%2Fs41386-020-0725-9/MediaObjects/41386_2020_725_Fig1_HTML.png)
Lowered endogenous mu-opioid receptor availability in subclinical depression and anxiety | Neuropsychopharmacology
![Researchers identify possible therapeutic target for depression and addiction - The Source - Washington University in St. Louis Researchers identify possible therapeutic target for depression and addiction - The Source - Washington University in St. Louis](https://news.wustl.edu/news/PublishingImages/Neuron%20preview%203%20crop_primary.jpg)
Researchers identify possible therapeutic target for depression and addiction - The Source - Washington University in St. Louis
![Opioid receptor modulation of neural circuits in depression: What can be learned from preclinical data? - ScienceDirect Opioid receptor modulation of neural circuits in depression: What can be learned from preclinical data? - ScienceDirect](https://ars.els-cdn.com/content/image/1-s2.0-S0149763419306323-gr5.jpg)
Opioid receptor modulation of neural circuits in depression: What can be learned from preclinical data? - ScienceDirect
![Frontiers | Traumatic Stress-Induced Vulnerability to Addiction: Critical Role of the Dynorphin/Kappa Opioid Receptor System Frontiers | Traumatic Stress-Induced Vulnerability to Addiction: Critical Role of the Dynorphin/Kappa Opioid Receptor System](https://www.frontiersin.org/files/Articles/856672/fphar-13-856672-HTML/image_m/fphar-13-856672-g001.jpg)
Frontiers | Traumatic Stress-Induced Vulnerability to Addiction: Critical Role of the Dynorphin/Kappa Opioid Receptor System
![Chronic Kappa opioid receptor activation modulates NR2B: Implication in treatment resistant depression | Scientific Reports Chronic Kappa opioid receptor activation modulates NR2B: Implication in treatment resistant depression | Scientific Reports](https://media.springernature.com/m685/springer-static/image/art%3A10.1038%2Fsrep33401/MediaObjects/41598_2016_Article_BFsrep33401_Fig1_HTML.jpg)
Chronic Kappa opioid receptor activation modulates NR2B: Implication in treatment resistant depression | Scientific Reports
![Kappa Opioid Receptor Ligands and Pharmacology: Diphenethylamines, a Class of Structurally Distinct, Selective Kappa Opioid Ligands | SpringerLink Kappa Opioid Receptor Ligands and Pharmacology: Diphenethylamines, a Class of Structurally Distinct, Selective Kappa Opioid Ligands | SpringerLink](https://media.springernature.com/lw685/springer-static/image/chp%3A10.1007%2F164_2020_431/MediaObjects/500126_1_En_431_Fig1_HTML.png)
Kappa Opioid Receptor Ligands and Pharmacology: Diphenethylamines, a Class of Structurally Distinct, Selective Kappa Opioid Ligands | SpringerLink
![Figure 4 | A Narrative Pharmacological Review of Buprenorphine: A Unique Opioid for the Treatment of Chronic Pain | SpringerLink Figure 4 | A Narrative Pharmacological Review of Buprenorphine: A Unique Opioid for the Treatment of Chronic Pain | SpringerLink](https://media.springernature.com/full/springer-static/image/art%3A10.1007%2Fs40122-019-00143-6/MediaObjects/40122_2019_143_Fig4_HTML.png)
Figure 4 | A Narrative Pharmacological Review of Buprenorphine: A Unique Opioid for the Treatment of Chronic Pain | SpringerLink
![Opioid receptor modulation of neural circuits in depression: What can be learned from preclinical data? - ScienceDirect Opioid receptor modulation of neural circuits in depression: What can be learned from preclinical data? - ScienceDirect](https://ars.els-cdn.com/content/image/1-s2.0-S0149763419306323-gr3.jpg)
Opioid receptor modulation of neural circuits in depression: What can be learned from preclinical data? - ScienceDirect
![In major depression, increased kappa and mu opioid receptor levels are associated with immune activation | Acta Neuropsychiatrica | Cambridge Core In major depression, increased kappa and mu opioid receptor levels are associated with immune activation | Acta Neuropsychiatrica | Cambridge Core](https://static.cambridge.org/binary/version/id/urn:cambridge.org:id:binary:20200227120957045-0270:S0924270819000474:S0924270819000474_tab4.png?pub-status=live)
In major depression, increased kappa and mu opioid receptor levels are associated with immune activation | Acta Neuropsychiatrica | Cambridge Core
![Early life stress dysregulates kappa opioid receptor signaling within the lateral habenula - ScienceDirect Early life stress dysregulates kappa opioid receptor signaling within the lateral habenula - ScienceDirect](https://ars.els-cdn.com/content/image/1-s2.0-S2352289520300576-fx1.jpg)
Early life stress dysregulates kappa opioid receptor signaling within the lateral habenula - ScienceDirect
The Role of Dynorphin and the Kappa Opioid Receptor in Schizophrenia and Major Depressive Disorder: A Translational Approach | SpringerLink
![κ Opioid Receptor-Dynorphin Signaling in the Central Amygdala Regulates Conditioned Threat Discrimination and Anxiety | eNeuro κ Opioid Receptor-Dynorphin Signaling in the Central Amygdala Regulates Conditioned Threat Discrimination and Anxiety | eNeuro](https://www.eneuro.org/content/eneuro/8/1/ENEURO.0370-20.2020/F3.large.jpg)
κ Opioid Receptor-Dynorphin Signaling in the Central Amygdala Regulates Conditioned Threat Discrimination and Anxiety | eNeuro
![Frontiers | A Trigger for Opioid Misuse: Chronic Pain and Stress Dysregulate the Mesolimbic Pathway and Kappa Opioid System Frontiers | A Trigger for Opioid Misuse: Chronic Pain and Stress Dysregulate the Mesolimbic Pathway and Kappa Opioid System](https://www.frontiersin.org/files/MyHome%20Article%20Library/215259/215259_Thumb_400.jpg)
Frontiers | A Trigger for Opioid Misuse: Chronic Pain and Stress Dysregulate the Mesolimbic Pathway and Kappa Opioid System
![Dynorphin/Kappa Opioid Receptor Signaling in Preclinical Models of Alcohol, Drug, and Food Addiction - ScienceDirect Dynorphin/Kappa Opioid Receptor Signaling in Preclinical Models of Alcohol, Drug, and Food Addiction - ScienceDirect](https://ars.els-cdn.com/content/image/1-s2.0-S0074774217301393-f03-05-9780128124734.jpg)
Dynorphin/Kappa Opioid Receptor Signaling in Preclinical Models of Alcohol, Drug, and Food Addiction - ScienceDirect
Structure-Based Discovery of New Antagonist and Biased Agonist Chemotypes for the Kappa Opioid Receptor | Journal of Medicinal Chemistry
![Frontiers Publishing Partnerships | Mechanisms Underlying the Anti-Suicidal Treatment Potential of Buprenorphine Frontiers Publishing Partnerships | Mechanisms Underlying the Anti-Suicidal Treatment Potential of Buprenorphine](https://www.frontierspartnerships.org/files/Articles/10009/adar-01-10009-HTML-r4/image_m/adar-01-10009-g001.jpg)